TABLE 1.
MICs for M. tuberculosis complex standard strainsa
| Strain | MIC (μg/ml) |
||||||
|---|---|---|---|---|---|---|---|
| OPC-167832 | DMD | RIF | BDQ | LVX | MXF | LZD | |
| M. tuberculosis | |||||||
| ATCC 27294 (H37Rv) | 0.0005 | 0.004 | 0.25 | 0.063 | 0.5 | 0.5 | 1 |
| ATCC 35812 (Kurono) | 0.0005 | 0.004 | 0.25 | 0.063 | 0.5 | 0.13 | 1 |
| ATCC 35838 (H37Rv RIF-R) | 0.0005 | 0.004 | >16 | 0.063 | 0.5 | 0.25 | 0.5 |
| ATCC 35822 (H37Rv INH-R) | 0.00024 | 0.004 | 0.5 | 0.063 | 0.5 | 0.25 | 1 |
| ATCC 35837 (H37Rv EMB-R) | 0.002 | 0.004 | 0.25 | 0.063 | 0.5 | 0.25 | 0.5 |
| ATCC 35820 (H37Rv SM-R) | 0.001 | 0.004 | 0.25 | 0.063 | 0.5 | 0.5 | 0.5 |
| ATCC 35828 (H37Rv PZA-R) | 0.001 | 0.004 | 1 | 0.13 | 0.5 | 0.5 | 1 |
| M. africanum ATCC 25420 | 0.002 | 0.001 | 0.25 | 0.25 | 0.25 | 0.25 | 0.5 |
| M. bovis ATCC BAA-935 | 0.002 | 0.004 | 0.063 | 0.13 | 0.25 | 0.13 | 0.5 |
| M. caprae ATCC BAA-824 | 0.001 | 0.002 | 0.13 | 0.13 | 0.25 | 0.063 | 0.25 |
| M. microti ATCC 11152 | 0.001 | 0.002 | 0.13 | 0.063 | 0.25 | 0.063 | 0.5 |
| M. pinnipedii ATCC BAA-688 | 0.0005 | 0.002 | 0.5 | 0.13 | 0.25 | 0.25 | 1 |
a
The MICs of OPC-167832 against M. tuberculosis complex standard strains were determined by an agar proportion method (CLSI document M24-A2 [35]). The MIC was determined as the lowest concentration of a compound inhibiting at least 99% of bacterial growth.