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Pharmacokinetic parameters of ibrexafungerp after single-dose intravenous administration of 7.5, 15, and 30 mg/kg/day in healthy rabbits
| Dose of Ibrexafungerp (mg/kg) | AUC(0-24) (ng·h/ml) | Cmax (ng/ml) | CL (liters/h) | V (liters) |
|---|---|---|---|---|
| 7.5 | 90,338 ± 15,048 | 38,533 ± 5,282 | 0.28 ± 0.03 | 1.08 ± 0.12 |
| 15 | 128,563 ± 11,718 | 45,466 ± 3,443 | 0.38 ± 0.02 | 1.66 ± 0.07 |
| 30 | 292,629 ± 28,167 | 85,583 ± 7,478 | 0.34 ± 0.04 | 1.85 ± 0.13 |
