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Predictions of ΔΔQTc changes at Cmax of contezolid based on PK/PD models in contezolid 800- and 1,600-mg treatment groups
| Treatment dose | Mean Cmax (mg/liter) | Corrected method | Placebo-adjusted change (ms) from baseline |
||
|---|---|---|---|---|---|
| Predicteda | Lower CI | Upper CI | |||
| Contezolid, 800 mg | 26.5 | QTcF | 7.42 | 6.56 | 8.27 |
| QTcI | 7.35 | 6.50 | 8.20 | ||
| QTcB | 4.85 | 3.81 | 5.88 | ||
| Contezolid, 1,600 mg | 44 | QTcF | 11.39 | 9.96 | 12.81 |
| QTcI | 10.97 | 9.56 | 12.38 | ||
| QTcB | 9.36 | 7.64 | 11.08 | ||
The predicted mean effect at mean Cmax.
