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. 2020 Jun 2;8(1):e000367. doi: 10.1136/jitc-2019-000367

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© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See https://creativecommons.org/licenses/by/4.0/.

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Characteristics of clinical response and survival. (A) Highest percentage change in the change in target lesion size from baseline in patients from cohort A and cohort B; horizontal dotted lines denote a 30% decrease and 20% increase, indicating objective response and progressive disease, respectively, as per RECIST version 1.1. (B) Percentage change in target lesion tumor size from baseline over time for all evaluable patients, defined as those with baseline tumor assessments and at least one post-treatment assessment. The upper horizontal dotted line indicates disease progression at a 20% increase in the size of target lesions, and the lower dotted line represents an objective response at a 30% decrease in the size of target lesions. (C) Time to response and duration of response in patients from cohort A and cohort B. (D) Kaplan-Meier curves of investigator-assessed progression-free survival in all evaluable patients (upper left). Kaplan-Meier curves of investigator-assessed overall survival in all evaluable patients (upper right). Comparison of the median progression-free survival (mPFS) between cohort A and cohort B (low left). Comparison of the median overall survival (mOS) between cohort A and cohort B (low right). RECIST, Response Evaluation Criteria in Solid Tumors.