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. 2020 Jun 2;8(1):e000543. doi: 10.1136/jitc-2020-000543

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© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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The clinical relevance of macrophage (MΦ) signaling axes regulated by transcription factor EB (TFEB). (A) The prognostic value of TFEB and the genes regulated by TFEB for patients with breast cancer based on the CTGA Human Protein Atlas database. (B) The prognostic value of TFEB and the genes regulated by TFEB for patients with breast cancer based on the online survival analysis platform www.kmplot.com. (C) A schematic drawing depicting how TFEB regulates macrophage functions in breast tumors. Arg1, arginase 1; COX2, cyclo-oxygenase-2; cPLA2, cytosolic phospholipases A2; HIF-1α, hypoxia-inducible factor 1α; IL, interleukin; NLRP3, NLR Family Pyrin Domain Containing 3; PGE, prostaglandin E2; PPARγ, peroxisome proliferator-activated receptor γ; SOCS3, suppressor of cytokine signaling 3.