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. 2020 Feb 4;130(3):1453–1460. doi: 10.1172/JCI134165

Figure 1. Relationships among hepatic DNL and metabolic characteristics.

Figure 1

(A) Relative contribution of DNL to IHTG content, assessed as palmitate produced by DNL, measured in plasma TG–rich lipoprotein TGs (TRL-TGs) in 3 groups of subjects: lean with normal IHTG content (Lean; n = 14); obese with normal IHTG content (Obese; n = 26); and obese with NAFLD (Obese-NAFLD; n = 27). Values indicate the mean ± SEM. One-way ANOVA was performed to compare the relative contribution of DNL to TRL-TG palmitate, with Tukey’s post hoc test used to identify significant mean differences between groups. *Value significantly different from the lean group value, P < 0.05. †Value significantly different from the obese group value, P < 0.01. Relationships between hepatic DNL, assessed as the percentage of contribution of DNL to plasma TRL-TG palmitate and (B) IHTG content; (C) whole-body insulin sensitivity, assessed as the glucose Rd during a HECP; (D) HISI; and integrated 24-hour AUCs for plasma (E) insulin and (F) glucose. Logarithmic regression analysis was used to determine the lines of best fit to the data. White, gray, and black circles represent participants in the lean, obese, and obese-NAFLD groups, respectively.