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. 2020 Feb 4;130(3):1446–1452. doi: 10.1172/JCI132360

Figure 1. Gldc deficiency results in ventriculomegaly.

Figure 1

Unlike wild-type (AE) and unaffected GldcGT1/GT1 (FJ) fetuses, a subset (7 of 13) of GldcGT1/GT1 fetuses (KO) were affected by enlargement of the lateral (Lv) and third (III) ventricles at E18.5. The fourth ventricle (IV, arrow in E) does not differ in size between genotypes (compare D with E, I with J, and N with O), nor does the aqueduct (aq) at this posterior axial level. Choroid plexus is detected in lateral, third, and fourth ventricles (arrows in B) of all genotypes. However, the pineal gland (pg) and subcommissural organ (arrowheads in C and H) are absent in GldcGT1/GT1 fetuses displaying ventriculomegaly (M). (PU) Following bilateral injection into the lateral ventricles of neonatal mice (P, Q, S, and T), dye distributed throughout the ventricular system including the fourth ventricle (IV) of Gldc+/+ (R) but not GldcGT1/GT1 (U) mice. Scale bars: 1 mm (C, H, and M), 5 mm (PU), and 0.5 mm (other panels).