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. 2020 Feb 10;130(3):1479–1490. doi: 10.1172/JCI130206

Figure 2. Canonical versus intron-derived miRNA production pathway.

Figure 2

Schematic diagrams of canonical miRNA processing pathway (left) and the intronic miRNA (mirtrons) processing pathway (right). Mirtrons are processed by the spliceosome in a manner completely independent of the microprocessor. Both pre-miRNAs and pre-mirtrons are then exported to the cytoplasm and further processed by DICER1. A close-up representation of the microprocessor in trimeric state (2 molecules of DGCR8 and 1 DROSHA) and the pri-miRNA are shown in the inset.