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. 2020 Jan 27;130(3):1288–1300. doi: 10.1172/JCI125607

Figure 3. Effect of tolerance induction on humoral response to GALNS.

Figure 3

Oral tolerance (OT) was induced by feeding MKC mice with 50, 100, or 500 μg of peptide I10 (red) or GALNS enzyme (blue). Control groups were fed with PBS (gray and purple). One week after the last oral dose, mice received 16 weekly intravenous infusions of human GALNS (red, blue, and gray) or PBS (purple). The induction of tolerance was evaluated in plasma samples after 16 intravenous infusions by (A) levels of IgG specific for GALNS and (B) levels of IgE specific for GALNS. Quantitative data are represented as a box-and-whisker plot, with bounds from 25th to 75th percentile, median line, and whiskers ranging from 5th and 95th percentile values of the average of 2 measurements for each mouse, n = 3 mice per treatment group. *P < 0.01, Benjamini and Hochberg adjusted, for differences between tolerized and nontolerized (PBS-ERT) mice. §P < 0.02, Benjamini and Hochberg adjusted, for differences between ERT-treated mice and untreated (PBS-PBS) mice.