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. 2020 Jan 27;130(3):1288–1300. doi: 10.1172/JCI125607

Figure 5. Circulating immune complexes in plasma.

Figure 5

Quantities of M complement proteins C1q, C3, C4, and C5 bound to circulating immune complexes (CICs) were measured using a Preceptor CIC ELISA kit. Oral tolerance was induced by feeding MKC mice with 50, 100, or 500 μg of peptide I10 (red) or GALNS enzyme (blue). Control groups were fed with PBS (gray and purple). One week after the last oral dose, mice received 16 weekly intravenous infusions of human GALNS (red, blue, and gray) or PBS (purple). Blood samples were obtained 10 days after the last infusion. Control naive MKC mice did not undergo any treatment (orange). Data are shown as scatter plots with mean ± 95% CI. Each scatter plot represents the average of 10 measurements from 5 mice. *P < 0.05, Benjamini and Hochberg adjusted, for differences between tolerized and nontolerized (PBS-ERT) mice. §P < 0.007, Benjamini and Hochberg adjusted, for differences between ERT-treated mice and untreated (PBS-PBS) mice.