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. 2020 Feb 10;130(3):1252–1270. doi: 10.1172/JCI131507

Figure 2. Vascular ZEB1 expression correlates negatively with survival rates in lung cancer patients.

Figure 2

(A) Representative examples of ZEB1 (red) and CD31 (brown) immunohistochemical staining of human lung cancer tissue arrays (n = 91) and matched adjacent normal samples (n = 88). Magnified areas of red boxed sections are shown in right panels. Arrowheads show ZEB1+ tumor ECs. (B) Comparison of vascular ZEB1 expression in lung cancer tissues versus matched adjacent normal tissues as described in A. (C) Comparison of vascular ZEB1 expression in lung cancer tissues with different pathological gradings as described in A. (D) Comparison of vascular ZEB1 expression in lung cancer tissues of patients with metastases versus patients without metastases as described in A. (E) Kaplan-Meier survival analysis of the relationship between overall survival rate and vascular ZEB1 expression in lung cancer patients as described in A. The cutoff value is the average vascular ZEB1 expression level of all patients. (F) Correlation plot between vascular ZEB1 expression and lung cancer patient survival time. All data are represented as mean ± SD. Differences were tested using unpaired 2-tailed Student’s t test (B and D), 1-way ANOVA with Tukey’s post hoc test (C), log-rank test (E), and 2-tailed Pearson test (F).