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. 2020 Feb 17;130(3):1527–1541. doi: 10.1172/JCI132990

Figure 3. N-acetylcysteine (NAC) levels in aqueous humor.

Figure 3

The dose of NAC was 600 mg twice a day for 12 weeks and then 600 mg 3 times a day for the subsequent 12 weeks in cohort 1 (A), 1200 mg twice a day for 12 weeks and then 1200 mg 3 times a day for the subsequent 12 weeks in cohort 2 (B), and 1800 mg twice a day for 12 weeks and then 1800 mg 3 times a day for the subsequent 12 weeks in cohort 3 (C). At each visit during the treatment period, an aqueous sample was obtained and NAC concentration was measured by LC-MS. The colored circles corresponding to patient identifiers show aqueous NAC levels in study eyes at each visit. Bars show the mean for each time point. The number of eyes (n) for each time point is shown along the x axis. Aqueous NAC was below the limit of quantification (20 ng/mL) for all subjects (except for the cohort 3 subject who exited at week 12 for whom no samples were available) at weeks 28, 32, and 36.