Summary of the significant changes in regional cerebral blood flow (rCBF) of WAS/EX vs. WAS/no-EX rats during passive bladder filling as related to a simplified model of the micturition circuit, and its cortical, limbic and reflex loops. Data are summarized from the SPM analysis shown in Fig. 4, with black shading indicating significant increases in rCBF and gray shading indicating significant decreases in rCBF. Abbreviations: A5 (A5 noradrenaline cells), Cx (cortex), dl-PAG, (dorsolateral periaqueductal gray), HPC (hippocampus), Hypoth (hypothalamus), LCC (locus coeruleus complex), MPO (medial preoptic nucleus), PFC (prefrontal cortex), vl-PAG (ventrolateral periaqueductal gray), PMC (pontine micturition center, Barrington nucleus complex), RN (red nucleus), rCBF (regional cerebral blood flow). Adapted from Griffiths [29], DeGroat et al. [30] and Zare et al. [31], with lines between boxes delineating known major neuronal pathways connecting each region.