Tau-related change in eigenvector and closeness centrality. (A–B). Cortical rendering of eigenvector and closeness centrality in beta and gamma bands, respectively. (C–D). Scatterplots showing the relationship between the metrics and Tau uptake for the group mean of the metrics and Tau levels for all the nodes. Plots show that the centrality values are lower on the posterior part of the brain, in the inferior parietal lobule and occipital cortex both medially and laterally. Abbreviations: ECEN, eigenvector centrality; CCEN, closeness centrality; FRO, frontal; LIM, limbic; OCC, occipital; PAR, parietal; TEM, temporal; γ, gamma; β, beta; BPND, nondisplaceable binding potential.