TABLE 3.
Selected Pearson correlation coefficients between prepregnancy BMI and third-trimester iron and inflammatory indicators by prepregnancy BMI category1
| Prepregnancy nonobese (n = 29) | Prepregnancy obese (n = 21) | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BMI | Log 57Fe utilization, % | Adjusted log ferritin,2 μg/L | Adjusted log sTFR,2 nmol/L | Hepcidin, ng/mL | Log IL-6, pg/mL | EPO, mIU/mL | BMI | Log 57Fe Utilization, % | Adjusted log ferritin,2μg/L | Adjusted log sTFR,2, nmol/L | Hepcidin, ng/mL | Log IL-6, pg/mL | EPO, mIU/mL | |
| BMI | 0.18 | −0.06 | −0.26 | 0.24 | 0.09 | −0.003 | −0.23 | 0.25 | −0.31 | −0.26 | 0.48* | −0.09 | ||
| Log 57Fe utilization, % | 0.18 | −0.01 | 0.10 | −0.11 | 0.02 | 0.13 | −0.23 | −0.44* | 0.08 | −0.48* | −0.29 | 0.17 | ||
| Adjusted log ferritin,2 μg/L | −0.06 | −0.01 | −0.30 | 0.34 | −0.19 | −0.34 | 0.25 | −0.44* | −0.20 | 0.35 | 0.13 | −0.31 | ||
| Adjusted log sTFR,2 nmol/L | −0.26 | 0.10 | −0.30 | −0.01 | 0.15 | 0.68* | −0.31 | 0.08 | −0.20 | 0.08 | −0.19 | 0.45* | ||
| Hepcidin, ng/mL | 0.24 | −0.11 | 0.34 | −0.01 | 0.02 | −0.02 | −0.26 | −0.48* | 0.35 | 0.08 | 0.03 | −0.23 | ||
| Log IL-6, pg/mL | 0.09 | 0.02 | −0.19 | 0.15 | 0.02 | 0.06 | 0.48* | −0.29 | 0.13 | −0.19 | 0.03 | 0.05 | ||
| EPO, mIU/mL | −0.003 | 0.13 | −0.34 | 0.68* | −0.02 | 0.06 | −0.09 | 0.17 | −0.31 | 0.45* | −0.23 | 0.05 | ||
Values presented are r, coefficients of correlation, *P < 0.05. BMI, prepregnancy body mass index; EPO, serum erythropoietin; hs-CRP, serum high-sensitivity C-reactive protein; sTFR, log-transformed serum soluble transferrin receptor.
Adjusted using the BRINDA (Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia) correction factor methods (33–35).