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ASM inhibition by ARC39 in vivo. ARC39 was applied intraperitoneally every 12 h for 96 h at a dose of 0.16 mM 10 μl/g and sphingomyelin content was determined by MS 12 h after the last injection. Data are represented as mean ± SD, n = 4 mice per group. Unpaired Student’s t-test was used. *P < 0.05 **P < 0.01.
