Table 2.
The relationship between SCL25A18 expression and clinicopathological characteristics of CRC cases from the TCGA database
| Clinic pathological characteristics | Expression level of SLC25A18 mRNA | Number of cases | P-value | |
|---|---|---|---|---|
|
| ||||
| High (%) | Low (%) | |||
| Gender | ||||
| Male | 213 (34.4) | 116 (18.7) | 619 | 0.4369 |
| Female | 179 (28.9) | 111 (17.9) | ||
| Primary Site | ||||
| Colon | 290 (47.2) | 163 (26.5) | 615 | 0.5102 |
| Rectal | 99 (16.1) | 63 (10.2) | ||
| Histological type | ||||
| Colon Adenocarcinoma | 248 (40.8) | 139 (22.9) | 608 | 0.4629 |
| Colon Mucinous Adenocarcinoma | 41 (6.7) | 21 (3.5) | ||
| Rectal Adenocarcinoma | 86 (14.1) | 60 (9.9) | ||
| Rectal Mucinous Adenocarcinoma | 10 (1.6) | 3 (0.5) | ||
| Ethnicity | ||||
| White | 130 (35.1) | 162 (43.8) | 370 | 0.8831 |
| Non-White | 34 (9.2) | 44 (11.9) | ||
| Pathologic T stage | ||||
| T1 and T2 | 96 (15.5) | 29 (4.7) | 618 | 0.0004**** |
| T3 and T4 | 295 (47.7) | 198 (32) | ||
| Pathologic N stage | ||||
| N0 | 234 (37.9) | 117 (18.9) | 617 | 0.0401** |
| N1 and N2 | 156 (25.2) | 110 (17.8) | ||
| Pathologic M stage | ||||
| M0 | 301 (55.0) | 158 (28.9) | 547 | 0.8844 |
| M1 | 57 (10.4) | 31 (5.7) | ||
| Microsatellite instability | ||||
| MSI | 5 (4.3) | 6 (5.2) | 116 | 0.9869 |
| MSS | 48 (41.4) | 57 (49.1) | ||
| Residual tumor | ||||
| R0 | 307 (62.3) | 144 (29.2) | 493 | 0.1595 |
| R1 and R2 | 33 (6.7) | 9 (1.8) | ||
| Survival status | ||||
| Alive | 355 (57.4) | 199 (32.2) | 618 | 0.3243 |
| Dead | 37 (6.0) | 27 (4.4) | ||
| Vascular invasion | ||||
| Yes | 82 (15.3) | 50 (9.3) | 537 | 0.7824 |
| No | 257 (47.9) | 148 (27.6) | ||
| Lymphatic invasion | ||||
| Yes | 160 (28.7) | 68 (12.2) | 558 | 0.0113** |
| No | 197 (35.3) | 133 (23.8) | ||
| Perineural invasion | ||||
| Yes | 23 (10.0) | 37 (16.0) | 231 | 0.4105 |
| No | 76 (32.9) | 95 (41.1) | ||
| Tumor deposits | ||||
| Yes | 24 (8.2) | 25 (8.5) | 293 | 0.8540 |
| No | 116 (39.6) | 128 (43.7) | ||
| KRAS Mutation | ||||
| Yes | 13 (21.0) | 18 (29.0) | 62 | 0.6020 |
| No | 11 (17.7) | 20 (32.3) | ||
| BRAF Mutation | ||||
| Yes | 1 (2.9) | 2 (5.7) | 35 | 0.5460 |
| No | 6 (17.1) | 26 (74.3) | ||
| Mismatch repair protein present | ||||
| Yes | 36 (7.6) | 28 (5.9) | 471 | 0.0072*** |
| No | 296 (62.8) | 111 (23.6) | ||
Clinical data were investigated using chi-square test.
**
P < 0.05;
***
P < 0.01;
****
P < 0.001.