Table 4.

Potential risk factors affecting the development of hand-foot syndrome determined by Cox proportional hazards regressio

Clinical factors	Univariate		Multivariate
	HR (95% CI)	P value	HR (95% CI)	P value
Gender	2.652 (1.236-5.692)	0.012	2.111 (0.973-4.579)	0.059
Age	1.003 (0.980-1.027)	0.795		NA
Length of sorafenib treatment	1.000 (0.999-1.000)	0.928		NA
Administration of celecoxib	0.384 (0.212-0.696)	0.002	0.414 (0.226-0.757)	0.004