Table 4.

Stratified analysis for associations of APOB genotypes and CDH13 haplotypes with survival of NSCLC patients

Characteristics	0–1 NUHGa			2 NUHGa			Multivariate analysis for OSb		Pinter c	Multivariate analysis for DSSb		Pinter c
	All	OS	DSS	All	OS	DSS	HR (95% CI)	P		HR (95% CI)	P
Age (years)
≤ 71	479	290	258	155	109	101	1.27 (1.01–1.59)	0.039		1.26 (1.00–1.60)	0.051
> 71	401	286	258	140	104	92	1.52 (1.20–1.91)	0.0004	0.408	1.50 (1.18–1.92)	0.001	0.321
Sex
Male	526	381	336	169	124	108	1.28 (1.04–1.57)	0.019		1.25 (1.01–1.56)	0.044
Female	354	195	180	126	89	85	1.74 (1.34–2.25)	<0.0001	0.390	1.75 (1.34–2.29)	<0.0001	0.348
Smoking status
Never	86	46	45	28	16	15	0.92 (0.50–1.72)	0.802		0.88 (0.47–1.66)	0.694
Current	311	198	171	106	68	64	1.18 (0.88–1.57)	0.266		1.27 (0.94–1.72)	0.116
Former	483	332	300	161	129	114	1.62 (1.32–1.99)	<0.0001	0.026	1.56 (1.25–1.94)	<0.0001	0.050
Histology
Adeno	432	249	226	143	97	95	1.56 (1.23–1.99)	0.0003		1.63 (1.27–2.08)	0.0001
Squamous	216	146	127	68	45	34	1.07 (0.76–1.51)	0.693		0.86 (0.58–1.27)	0.439
Others	232	181	163	84	71	64	1.63 (1.22–2.16)	0.0009	0.659	1.66 (1.23–2.25)	0.001	0.472
Tumor stage
I-III	491	224	179	163	90	74	1.37 (1.06–1.76)	0.015		1.36 (1.03–1.79)	0.033
IV	389	352	337	132	123	119	1.39 (1.12–1.72)	0.002	0.293	1.39 (1.12–1.73)	0.003	0.357
Chemotherapy
No	478	260	217	160	106	90	1.72 (1.36–2.17)	<0.0001		1.65 (1.28–2.12)	0.0001
Yes	402	316	299	135	107	103	1.14 (0.91–1.42)	0.254	0.0006	1.15 (0.92–1.45)	0.222	0.002
Radiotherapy
No	567	320	275	194	129	116	1.43 (1.16–1.76)	0.0007		1.47 (1.18–1.83)	0.0007
Yes	313	256	241	101	84	77	1.35 (1.05–1.75)	0.019	0.536	1.29 (0.99–1.68)	0.058	0.276
Surgery
No	474	424	401	161	141	133	1.23 (1.01–1.49)	0.038		1.21 (0.99–1.48)	0.059
Yes	406	152	115	134	72	60	1.78 (1.33–2.37)	<0.0001	0.147	1.89 (1.37–2.60)	<0.0001	0.092

Abbreviations: OS, overall survival; DSS, disease-specific survival; NSCLC, non-small cell lung cancer; HR, hazards ratio; CI, confidence interval; NUGH, number of unfavorable genotypes/haplotypes.

^aTen missing data were excluded;

^bAdjusted for age, sex, stage, histology, smoking status, chemotherapy, radiotherapy, surgery, PC1, PC2, PC3, and PC4;

^cP inter: P value for interaction analysis between characteristic and UHG.