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. Author manuscript; available in PMC: 2020 Dec 1.
Published in final edited form as: Clin Cancer Res. 2020 Jan 22;26(11):2595–2602. doi: 10.1158/1078-0432.CCR-19-1669

Figure 2. p27 immunostaining in African-American prostate tumors with CDKN1B deep deletions.

Figure 2.

Both cases showed deep deletions of CDKN1B by sequencing, however the tumor on the left demonstrates homogeneous loss of p27 protein, suggestive of a clonal alteration, while the tumor on the right shows heterogeneous loss of p27 in some (arrow) but not all (arrowhead) tumor cells, suggestive of a subclonal alteration in CDKN1B. In both cases, benign glands (B) provide an internal positive control for p27 staining. All images reduced from 200x magnification.