Table 2.
Percent genome alteration in JHMI AA cohort (n=205) and TCGA cohort (n=313) by pathologic grade.
| JHMI AA (n=205) | TCGA AA (n=43) | TCGA EA (n=270) | ||||
|---|---|---|---|---|---|---|
| PGA, median (IQR) | p-value | PGA, median (IQR) | p-value | PGA, median (IQR) | p-value | |
| Total | 3.74 (0.93–9.35) | 6.48 (0.45–12.34) | 0.877^ | 6.08 (1.74–11.71) | ||
| RP grade group | <0.001* | <0.001* | <0.001* | |||
| 1 | 0.94 (0–4.21) | 0.61 (0.004–6.39) | 0.486^ | 2.11 (0.05–4.99) | ||
| 2 | 1.87 (0–3.27) | 3.89 (0.09–7.53) | 0.480^ | 4.68 (1.36–7.94) | ||
| 3 | 3.74 (0.94–10.28) | 9.57 (6.34–16.73) | 0.154^ | 6.94 (2.68–11.38) | ||
| 4 | 8.41 (2.80–11.22) | 12.03 (8.86–15.51) | 0.780^ | 13.74 (7.40–22.20) | ||
| 5 | 4.67 (0.94–9.35) | 26.2 (15.2–34.9) | 0.032^ | 8.97 (3.53–17.90) | ||
*
P-value signifies Kruskal Wallis calculation to detect differences in PGA between grade groups within each cohort.
^
P-value signifies rank sum calculation to detect differences in PGA between TCGA AA and TCGA EA cohorts within each grade group.