. Author manuscript; available in PMC: 2020 Dec 1.

Published in final edited form as: Clin Cancer Res. 2020 Jan 22;26(11):2595–2602. doi: 10.1158/1078-0432.CCR-19-1669

Table 3.

Univariable and multivariable Cox proportional hazards models assessing association of PGA with metastasis

Variable	Univariable		Multivariable^*

	HR (95% CI)	p-value	HR (95% CI)	p-value

PGA (continuous) ^‡	1.11 (1.06, 1.17)	<0.001	1.15 (1.07, 1.23)	<0.001

PGA (quartile)^{^}
≤25^th percentile	1.00 (reference)	--	1.00 (reference)	--
25–50^th percentile	0.80 (0.07, 8.88)	0.859	0.58 (0.05, 6.43)	0.655
50–75^th percentile	5.28 (1.02, 27.41)	0.048	3.31 (0.60, 18.25)	0.170
>75^th percentile	14.43 (3.13, 66.65)	0.001	13.45 (2.55, 70.86)	0.002

Multivariable models were adjusted for age at RP, PSA, RP grade group <4 or ≥4, and pathologic stage. RP grade group was analyzed as dichotomous variable due to low number of metastatic events per grade group.

^‡

Per 1% change in PGA

^{^}

≤0.93% (≤25^th percentile), 0.94–3.74% (25^th-50^th percentile), 3.75–9.35% (50^th-75^th percentile), and >9.35% (>75^th percentile)