Table 4.

Univariable and multivariable Cox proportional hazards models assessing association of genetic alterations with metastasis.

Variable	Univariable		Multivariable*
	HR (95% CI)	p-value	HR (95% CI)	p-value
CDKN1B deep deletion	5.71 (1.23, 26.61)	0.026	6.66 (1.26, 35.22)	0.026
CHD1 deep deletion†	--	--	--	--
PTEN deep deletion	4.19 (0.94, 18.62)	0.060	5.16 (0.97, 27.48)	0.055
FOXA1 mutation	0.57 (0.08, 4.29)	0.586	0.34 (0.04, 2.76)	0.310
SPOP mutation	1.05 (0.30, 3.62)	0.942	1.34 (0.34, 5.32)	0.678
TP53 mutation	7.01 (2.01, 24.41)	0.002	9.45 (2.20, 40.55)	0.002

^*Multivariable models were adjusted for age at RP, PSA, RP grade group <4 or ≥4, and pathologic stage. RP grade group was analyzed as dichotomous variable due to low number of metastatic events per grade group.

^†No metastatic events were observed for CHD1 genetic alterations, hence HR and p-values were not calculated.