Table 4.
Final multivariable models for each manifestation of cardiovascular disease
| Type* | HR⍰ | 95% Cl | p-value | |
|---|---|---|---|---|
| MACE | ||||
| Diabetes Duration | B | 1.11 | 1.08, 1.15 | <.0001 |
| In(AER) | C | 1.32 | 1.19, 1.48 | <.0001 |
| Systolic BP | M | 1.03 | 1.01, 1.05 | <.0001 |
| White Blood Cell Count | B | 1.23 | 1.12, 1.36 | <.0001 |
| HbA1c | M | 1.20 | 1.02, 1.41 | 0.03 |
| LDLc | B | 1.01 | 1.001, 1.013 | 0.04 |
| Soft CAD | ||||
| Diabetes Duration | B | 1.13 | 1.10, 1.16 | <.0001 |
| Systolic BP | C | 1.03 | 1.01, 1.04 | 0.0002 |
| White Blood Cell Count | C | 1.17 | 1.08, 1.28 | 0.0003 |
| In(AER) | C | 1.18 | 1.05, 1.32 | 0.004 |
| HbA1c | C | 1.21 | 1.06, 1.39 | 0.005 |
| REV | ||||
| LDLc | B | 1.03 | 1.02, 1.03 | <.0001 |
| Diabetes Duration | B | 1.10 | 1.05, 1.16 | 0.0001 |
| eGFR | B | 0.98 | 0.97, 0.99 | 0.002 |
| HbA1c | C | 1.25 | 1.02, 1.23 | 0.03 |
| MACE+REV | ||||
| Diabetes Duration | B | 1.09 | 1.07, 1.12 | <.0001 |
| In(AER) | C | 1.32 | 1.21, 1.44 | <.0001 |
| Systolic BP | B | 1.03 | 1.01, 1.04 | <.0001 |
| LDLc | B | 1.01 | 1.005, 1.014 | <.0001 |
| White Blood Cell Count | B | 1.19 | 1.09, 1.30 | 0.0001 |
*
Variable type: B=baseline (fixed), C=current/most recent (time-varying), M=updated mean (time-varying)
⍰
Hazard Ratio