Table 2.

The Dramatic Effects of Silver Salts in the Presence of Pyridone Ligands^[a,b]

^[a]Conditions: 1a (0.2 mmol, 2.0 equiv), methyl 4-iodobenzoate (1.0 equiv), Pd(OAc)₂ (10 mol %), TDG1 (30 mol %), L9 (40 mol %), TFA (1.5 equiv), silver salt (2.0 equiv), HFIP (0.6 mL), 100 °C, under air, 24 h.

^[b]Yield determined by ¹H NMR analysis of the crude product using CH₂Br₂ as internal standard. [c] Ag₃PO₄ (1.0 equiv). [d] K₃PO₄ (1.0 equiv).