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. Author manuscript; available in PMC: 2021 Jun 8.
Published in final edited form as: Angew Chem Int Ed Engl. 2020 Apr 1;59(24):9594–9600. doi: 10.1002/anie.202000532

Table 3.

Transient directing group evaluation for enantioselective β-C(sp3)‒H Arylation of cyclobutyl ketones[a,b]

graphic file with name nihms-1584760-t0011.jpg
graphic file with name nihms-1584760-t0012.jpg
[a]

Conditions: 1a (0.2 mmol, 2.0 equiv), methyl 4-iodobenzoate (1.0 equiv), Pd(OAc)2 (10 mol %), TDG (30 mol %), L9 (40 mol %), TFA (1.5 equiv), Ag3PO4 (1.0 equiv), HFIP (0.6 mL), 100 °C, under air, 24 h.

[b]

Yield determined by 1H NMR analysis of the crude product using CH2Br2 as internal standard.