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. Author manuscript; available in PMC: 2021 Jun 8.
Published in final edited form as: Angew Chem Int Ed Engl. 2020 Apr 1;59(24):9594–9600. doi: 10.1002/anie.202000532

Table 5.

Scope of ketones[a,b]

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graphic file with name nihms-1584760-t0016.jpg
[a]

Conditions: 5 (0.2 mmol, 2.0 equiv), methyl 4-iodobenzoate (1.0 equiv), Pd(OAc)2 (10 mol %), TDG3 (30 mol %), L12 (40 mol %), TFA (1.5 equiv), Ag3PO4 (1.0 equiv), HFIP (0.6 mL), 100 °C, under air, 24 h.

[b]

Isolated yields.

[c]

Numbers in parentheses indicate the ratio of the arylation of the cyclobutane and terminal methyl group.

[d]

AgTFA (2.0 equiv).