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Effect of VSL#3 supplementation on brain concentrations of eicosanoids in C57BL/6 (WT) and AppNL-G-F mice. (a) PGD, (b) PGE2, (c) 6-keto PGF1α, (d) PGF2α, (e) thromboxane, (f) Arachidonic acid, and (g) Docosahexaenoic acid were measured using mass spectrometry in temporal cortices after 8 weeks of treatment. Data are represented as mean ± S.E.M. Significant differences were determined by two-way ANOVA, * p<0.05 (n=7 for AppNL-G-F mice and n=8 for WT mice).
