Supplemental Digital Content is available in the text
Keywords: legalization, marijuana, state-based differences
Objective:
Beliefs about marijuana use and prevalence of use may be associated with the legalization status of the state of residence. We examined differences in views and rates of use of marijuana among residents in recreationally legal, medically legal, and nonlegal states.
Methods:
We surveyed a nationally representative online panel of US adults (N = 16,280) and stratified results by marijuana legalization status of states. We compared views of residents of recreational states on benefits and risks of marijuana use to residents in other states.
Results:
The response rate was 56.3% (n = 9003). Residents in recreationally legal states were more likely to believe marijuana could be beneficial for pain management (73% in recreationally legal states, 67% in medically legal states, 63% in nonlegal states; P value: <0.0001), provide relief from stress, anxiety or depression (52% in recreationally legal states, 47% in medically legal states, 46% in nonlegal states; P value: 0.01), and improve appetite (39% in recreationally legal states, 36% in medically legal states, 33% in nonlegal states; P value: <0.009). In addition, residents in recreational states were significantly more likely to believe that smoking 1 marijuana joint a day is somewhat or much safer than smoking 1 cigarette a day (40.8% in recreationally legal states, 39.1% in medically legal states, and 36.1% in nonlegal states; P value: <0.0001). Residents of recreationally and medically legal states were more likely to believe second-hand marijuana smoke was somewhat or much safer than second-hand tobacco smoke (38.3% in recreationally legal states, 38.3% in medically legal states, and 35.7% in nonlegal states; P value: 0.003). Past-year marijuana use in any form (20% in recreational, 14.1% in medical, 12% in nonlegal) and past-year marijuana use of multiple forms (11.1% in recreational, 6.1% in medical, 4.9% in nonlegal) were highest among residents of recreationally legal states. Overall, prevalence of past-year use of any form of marijuana use was more common among residents of recreationally legal states compared with other states (20.3%, confidence interval [CI] 19.5, 21.1 in recreationally legal states; 15.4%, CI 14.7, 16.2 in medically legal states; 11.9%, CI 11.2, 12.6 in nonlegal states).
Conclusions:
Residents in recreationally legal states were most likely to believe marijuana has benefits, marijuana smoke is safer than tobacco smoke, and have the highest rate of marijuana use. This is cause for concern, given the tide of commercialization, growing number of high-potency cannabis products, and favorable media coverage promoting use for health problems.
Marijuana use is legal for medical or recreational purposes in 33 states and Washington, DC (National Conference of State Legislatures, 2019). Recreational legalization has ushered in rapid commercialization (Richter and Levy, 2014). Both Colorado and Washington—the first 2 states to legalize marijuana for recreational use—have seen retail sales exceed a billion dollars annually (Lewis, 2017). States with recreational marijuana have been inundated with mass marketing promoting marijuana use, and also an increase in novel marijuana products with tetrahydrocannabinol (THC) content at concentrations not evaluated for safety in humans (Steigerwald et al., 2018). Given the absence of federal regulations in managing the commercial marijuana market, individual states are developing regulations governing marijuana advertising, production, and sale (National Conference of State Legislatures, 2019).
In US adults, rates of recreational marijuana use and cannabis use disorders have increased considerably over the last several years (Charilaou et al., 2017; Hasin et al., 2017; Center for Behavioral Health Statistics and Quality, 2018). Legalization for medical purposes has been accompanied with increased daily use and marijuana use disorders among US adults (Chu, 2014; Wen et al., 2015; Martins et al., 2016; Hasin et al., 2017; Hasin, 2018). Approximately 15% of the US adult population used marijuana in some form in 2017 (Keyhani et al., 2018). Between 2016 and 2017, past-month use of marijuana increased nearly 2% among adults aged 18 to 25 years and 1.2% among adults 26 years and older (Center for Behavioral Health Statistics and Quality, 2018). Additionally, national surveys suggest the perception of “great risk” from weekly marijuana use dropped from 50.4% in 2002 to 33.3% in 2014 (Compton et al., 2016) and has dropped further since (Center for Behavioral Health Statistics and Quality, 2018). Recent national surveys also demonstrate that the public attributes benefits to marijuana that are not supported by existing scientific evidence, such as relief from anxiety, stress, and depression, improved appetite, and improved sleep (Keyhani et al., 2018).
It is unknown whether adult residents of states where marijuana has been commercialized for recreational use are more likely to attribute benefits to marijuana use. Given the growing body of evidence that adverse consequences are associated with regular marijuana use (40,Whiting et al., 2015; Wang et al., 2016; National Academies of Sciences, Engineering, and Medicine, 2017), determining whether residents of recreational states perceive marijuana use differently than residents of states without commercial legalization is an important consideration and may inform the needs for more investment in communications of potential risks to the public. In this study, we examine the differences in beliefs about marijuana use and rates of use across states defined by their marijuana legalization status (recreationally legal, medically legal, nonlegal).
METHODS
Survey Development
Survey questions were developed by identifying gaps in existing federally funded national surveys, including the National Survey on Drug Use and Health (NSDUH) and Monitoring the Future (MTF), and drafting questions to address those gaps. Questions were refined through interviews with marijuana industry professionals, dispensary staff, marijuana distributors, and mental health and substance use disorder experts. Survey items developed included individual opinions on the risks and benefits of marijuana use, comparisons of risks and benefits of marijuana to other psychoactive substances, and the form, amount, and frequency with which individuals use marijuana. In total, the survey included 29 questions assessing beliefs about the risks and benefits of marijuana and 54 questions assessing marijuana use. Answer options for all opinion questions used Likert scales to allow participants to respond with the answer most closely aligned with their beliefs. All questions were written at an 8th-grade reading level and were tested on a convenience sample of 40 adults to ensure readability and construct validity. Full details on survey development have been previously published (Keyhani et al., 2018). The survey tool is available in the supplementary material (Supplementary Questionnaire 1).
Sampling Strategy
We conducted a survey of a nationally representative sample of 16,280 US adults on risks and benefits of marijuana use. The survey was conducted using KnowledgePanel (GfK Custom Research North America)—a nationally representative panel of civilian, noninstitutionalized US adults aged 18 years and older that has been used to survey public opinion since 1999 (14,29,17,Fowler et al., 2013; McAfee et al., 2013; Hanauer et al., 2014; Tomlinson et al., 2015). GfK created a representative sample of US adults by random sampling of addresses (Fant et al., 1998). The address-based sampling covers 97% of the country and encompasses a statistical representation of the US population. Households without internet access are provided with an Internet connection and a tablet to ensure participation. All participants in the panel are sampled with a known probability of selection. No one can volunteer to participate. Participants are provided with no more than 6 surveys a month and are expected to complete an average of four surveys a month (further details on the sampling strategy of GFK's KnowledgePanel is provided here: (https://www.gfk.com/fileadmin/user_upload/dyna_content/US/documents/KnowledgePanel_Methodology.pdf). Sampling was stratified by legalization status of marijuana in the state of residence (ie, recreational, medical, and nonlegal) (Supplementary Table 1). California residents and young adults aged 18 to 26 years old were oversampled to facilitate a future investigation into the role of recreational legalization on use patterns among young adults in California. Sampling weights were provided by GfK.
Survey Administration
The survey was launched on September 27, 2017 to a total of 16,280 US adults 18 years and older, and was completed on October 9, 2017. The survey was administered using an online format. This study was considered exempt from review by the Committee on Human Subject Research, University of California, San Francisco.
Statistical Analysis
The response rate, determined using methods outlined by the American Association for Public Opinion Research, was the ratio of respondents to all potential participants (The American Association for Public Opinion Research, 2016). Characteristics of the survey respondents were weighted using weights provided by GfK to approximate the US population based on age, sex, race, ethnicity, education, household income, home ownership, and metropolitan area. All analyses used weighting commands using the weight variable provided by GfK to generate national estimates. We first compared the sociodemographic characteristics of our respondents to that of the NSDUH—an annual, federally funded epidemiologic survey (Center for Behavioral Health Statistics and Quality, 2018). We then compared views and forms of marijuana use of residents across recreational, medical, and nonlegal states using chi-square statistics. Finally, we reported the prevalence of different forms of use stratified by legalization status of states and the associated 95% confidence interval (CI). In supplementary analyses, using logistic regression, we examined views of residents of recreational states compared with other states after adjusting for baseline demographic characteristics including age, sex, race, employment status, and household size. All analyses were performed with R statistical software (version R-3.4.0).
RESULTS
Response Rate and Participant Characteristics
The response rate of the survey was 56.3% (n = 9003) and did not vary by status of legalization in state of residence (55.2%, 55.4%, 55.3% in recreationally legal, medically legal, and nonlegal states, respectively). The rate of missing or refused questions ranged from 0% to 3.9%. The sample was 52% female, 64% white, 12% black, 16% Hispanic, and 8% other race with a mean age of 48 years. Residents of the 3 state types did not differ by age. The residents of recreational states were predominantly white and less diverse than other state types (Supplementary Table 2). The residents of recreational states had higher rates of education and higher income levels compared with other state types. Sociodemographic characteristics of the respondents were largely similar to those of NSDUH, though our sample had a slightly higher average income (Supplementary Table 3).
Beliefs Regarding Benefits Associated With Marijuana Use
Overall, residents of states where marijuana was legalized for recreational purposes were more likely to endorse the belief that marijuana had benefits compared with residents of other states (Table 1). Specifically, residents in recreationally legal states were more likely to believe marijuana could be beneficial for pain management (73% in recreationally legal states, 67% in medically legal states, 63% in nonlegal states; P value: <0.0001); provide relief from stress, anxiety, or depression (52% in recreationally legal states, 47% in medically legal states, 46% in nonlegal states; P value: 0.01); and improve appetite (39% in recreationally legal states, 36% in medically legal states, 33% in nonlegal states; P value: <0.009). Pain management was endorsed as the most important benefit regardless of state of residence (39.7% in recreationally legal states, 36.7% in medically legal states, 30.7% in nonlegal states; P value: <0.0001). Residents of nonlegal states were more likely to endorse the belief that marijuana had no benefits compared with those in recreationally legal states (14%, 16%, 19% in recreationally legal, medically legal, and nonlegal states, respectively; P value: <0.001). Multivariate analyses confirmed that residents of recreational states were less likely to believe marijuana had “no benefits” and more likely to believe that marijuana use had benefits in pain management, helped with reducing or stopping other medications, provided relief from stress, anxiety, and depression, improved sleep and appetite, and improved creativity compared with residents of medical and nonlegal states after adjusting for baseline characteristics (Supplementary Table 4).
TABLE 1.
Views on Risk and Benefits of Marijuana Use among US Adults 18 Years and Older Categorized by State Legalization Status∗
Beliefs Regarding Risks Associated With Marijuana Use
The belief that marijuana use was associated with the development of addiction was similar across states (50% in recreationally legal states, 49% in medically legal states, 51% in nonlegal states; P value: 0.5) (Table 1). Residents of recreational, medical, and nonlegal states all endorsed addiction as the most important risk associated with use (19.3% in recreationally legal states, 22.1% in medically legal states, 20.5% in nonlegal states; P value: <0.0001). Multivariate analyses revealed that residents of recreational states were more likely to believe that marijuana use impaired memory, and also caused a decrease in intelligence and energy compared with residents of other medically legal and nonlegal states after adjusting for baseline characteristics (Supplementary Table 4).
Opinions of US Adults Regarding Public Health Domains Pertaining To Marijuana Use
Residents in recreational states were significantly more likely to believe that smoking one marijuana joint a day is somewhat or much safer than smoking 1 cigarette a day (40.8% in recreationally legal states, 39.1% in medically legal states, and 36.1% in nonlegal states) (Table 2). Residents of recreationally and medically legal states were more likely to believe second-hand marijuana smoke was somewhat or much safer than second-hand tobacco smoke (38.3% in recreationally legal states, 38.3% in medically legal states, and 35.7% in nonlegal states). Opinions regarding other relevant public health concerns were largely similar across states: most residents, regardless of legal status in state of residence, agreed that it is unsafe for children and adults to be exposed to second-hand marijuana smoke, and that marijuana use was unsafe for pregnant women. Multivariate analyses confirmed that residents of recreational states were more likely to believe that smoking 1 marijuana joint a day was safer than smoking 1 cigarette a day compared with residents of other medically legal and nonlegal states after adjusting for baseline characteristics (Supplementary Table 5). Residents of recreational states were also more likely to believe second-hand smoke from marijuana was safer than second-hand smoke from tobacco compared with residents of other medical and nonlegal states after adjusting for baseline characteristics (Supplementary Table 5).
TABLE 2.
Views of Americans on Important Public Health Domains Pertaining to Marijuana Use∗
Beliefs About The Preventive Health Benefits of Different Forms of Marijuana
Over half of US adults strongly or somewhat strongly agreed with the statement that marijuana, in the form of smoked, vaped, or edibles, had preventative health benefits. There were no significant differences in views on the preventative health benefits of different forms of marijuana between states (Table 3). Multivariate analyses demonstrated no differences across states in views on the preventative health benefits of different forms of marijuana (Supplementary Table 6).
TABLE 3.
Views of US Adults on Different Forms of Marijuana Preventing Health Problems∗
Prevalence of Use of Different Forms of Marijuana Between Residents in States With Differing Legal Status
Overall, prevalence of past-year use of any form of marijuana use was more common among residents of recreationally legal states compared with other states (20.3%, CI 19.5, 21.1 in recreationally legal states, 15.4%, CI 14.7, 16.2 in medically legal states, 11.9%, CI 11.2, 12.6 in nonlegal states) (Table 4). Use of several individual forms was also more common among residents in recreationally legal states. For example, prevalence of past-year use of edibles by residents in recreationally legal states was 11.3% (CI 10.6, 11.9) compared with 6.3% (CI 5.8, 6.8) among residents in medically legal states and 4.2% (CI 3.8, 4.6) among residents in nonlegal states.
TABLE 4.
Prevalence of Past-year Marijuana Use by Form∗
Likewise, prevalence of past-year use of multiple forms of marijuana was highest among residents in recreationally legal states (11.1%, CI 9.9, 12.4) compared with residents in medically legal states (7.2%, CI 6.2, 8.2) or nonlegal states (4.8%, CI 4.0, 5.7).
DISCUSSION
In this national study, we found that residents of states that had legalized recreational marijuana use more commonly attributed some benefit to marijuana than residents of medically legal or nonlegal states. We also found that the perception of risks from marijuana use was similar across states. In addition, we found that residents of states where marijuana was legalized were more likely to believe that marijuana smoke was less harmful than tobacco smoke. Finally, use of all forms and multiple forms of marijuana was more common among residents of recreationally legal states.
Several national surveys, including the NSDUH and MTF, assess individual risk perception of marijuana use among national samples, and recent research suggests that risk perception has decreased nationwide (5,Carliner et al., 2017; Sarvet et al., 2018). Previous research demonstrates that marijuana legalization is associated with decreases in risk perception, as evident from studies examining California pre and postmedical legalization in 1999 (Khatapoush and Hallfors, 2004). More recent research supports this assertion (5,Carliner et al., 2017; Sarvet et al., 2018), and while research into the role of recreational legalization specifically is limited, initial data in adolescents suggest recreational legalization has been associated with a considerable decrease in risk perception (Cerdá et al., 2017). While such surveys have adequately examined the decrease in risk perception associated with marijuana, there exists no detail on the types of risks individuals associate with marijuana use or potential benefits individuals assign to marijuana use. Our results show that residents of states where marijuana has been legalized for recreational use have an overall more favorable view towards potential benefits of marijuana use and were more likely to attribute benefits to marijuana use that are not supported by evidence. For example, a majority of respondents endorsed pain relief as a benefit of marijuana use, despite only limited evidence supporting its effect in managing chronic neuropathic pain and no evidence in treating other types of chronic pain (Nugent et al., 2017). There is no evidence currently available that suggests second-hand marijuana smoke is safer than tobacco smoke and some evidence suggesting it is toxic (Wang et al., 2016). There is no data suggesting that marijuana is an effective and safe treatment for insomnia (Whiting et al., 2015). When taken in context with previous research demonstrating the decrease in risk perception associated with marijuana use, our findings are significant as they illustrate the need for targeted public health campaigns to combat misinformation specifically in states with recreational marijuana legalization.
We found that residents of recreationally legal states expressed less concern regarding second-hand marijuana smoke compared with second-hand tobacco smoke, and were more likely to believe that smoking marijuana is somewhat or much safer than smoking tobacco. These differences in perception are concerning, given the evidence that inhalation of particulate matter in any form (smog, second-hand tobacco smoke, or smoking) is associated with increased cardiovascular risk (33,Pope et al., 2011; Kim et al., 2015). The perception that marijuana smoke is relatively safe compared with tobacco smoke has been perpetuated by the spread of inaccurate information on the internet (Loria and Welsh, 2015). Some highly frequented internet sites suggest that smoking marijuana has many health benefits, such as improvement of lung health or the slowing of Alzheimer symptoms (Loria, 2018). There is currently no data to suggest that smoking marijuana improves lung health. On the contrary, recent evidence demonstrates smoking marijuana is associated with coughing, wheezing, and sputum production (Ghasemiesfe et al., 2018). The lack of a clear federal public health response to the growing legalization of marijuana and proliferation of pro-marijuana marketing has left a vacuum that is filled by commercial interests (Bierut et al., 2017).
Unlike the tobacco industry, the marijuana industry has remained largely unchallenged by a coordinated regulatory response, and is aggressively advertising its product in states with rapidly expanding commercial markets (4,24,13,Bierut et al., 2017; Krauss et al., 2017; Fiala et al., 2018; Glantz et al., 2018). Over half of adults living in states with recreational marijuana are frequently exposed to pro-marijuana advertising in numerous forms (2,Abraham et al., 2018; Fiala et al., 2018), and research indicates that greater exposure to pro-marijuana advertising is associated with heavier marijuana use among adolescents and heavier use among adult persons who use (D’Amico et al., 2015; Krauss et al., 2017). More stringent regulations of marijuana product marketing, and also a cohesive public health messaging campaign, are necessary to combat misinformation and communicate the potential risks associated with marijuana use so consumers can make informed choices about use.
With the exception of smoking rates, which were roughly equivalent among residents in recreationally legal and medically legal states, prevalence of use among all forms of marijuana and use of multiple forms of marijuana was higher among residents in recreationally legal states. This is not surprising, given that novel forms of marijuana are more accessible in states with robust recreational markets. For example, in the first year with an active recreational marijuana market, Colorado dispensaries sold 4.81 million units of edible cannabis product (about 45% of the total annual sales) (Barrus et al., 2016). The popularity of marijuana products in forms other than smoking is a cause for some concern as such products are increasingly available with THC content at high levels not yet studied. Previous research suggests that some edible products exceed state-mandated THC thresholds and can reach as high as 7000 mg per package (Steigerwald et al., 2018). Given the growing popularity of marijuana in forms like edibles or extracts, increased focus should be directed towards understanding the health effects of THC at such concentrated levels. In the absence of evidence of harms, states may be reluctant to more stringently regulate the form and content of edible products.
There are several limitations to this study. The generalizability of our results may have been limited by the use of an internet survey as the population who choose to join an ongoing internet panel may be different from individuals who choose not to participate. However, GfK's KnowledgePanel has demonstrated no evidence of nonresponse bias in the panel on core demographic and socioeconomic variables (Heeren et al., 2008). We did not conduct reliability testing of the survey items. As a result, it is possible the interpretation of our questions might differ between participants. For example, though pain management was endorsed as the most important benefit across residents of all states, we did not distinguish between types of chronic pain, and this may have been interpreted differently between participants. Additionally, we did assess the extent of individual marijuana use among participants, medical reasons for use among marijuana users, and sources of information regarding beliefs about marijuana. However, the data were not sufficiently relevant when stratified by state legalization status. Furthermore, it is important to note that we did not differentiate between state legal status beyond the designation of “recreationally legal, medically legal, or nonlegal,” and marijuana accessibility can vary greatly within states with the same legal status due to differences in state-based implementation. Nonetheless, we found clear differences in opinions of residents of recreationally legal states compared with other states. Finally, the study was cross-sectional. Therefore, it is unknown if people in states where marijuana was legalized for recreational use developed their beliefs before legalization, which then led to legalization in their state, or if the opinions assessed in this survey were a result of recreational legalization of marijuana.
CONCLUSIONS
The US adults residing in recreationally legal states were most likely to believe marijuana has benefits and that marijuana smoke is safer than tobacco smoke. Residents of recreationally legal states had the highest rates of use of different forms of marijuana. The favorable views of residents in recreationally legal states are cause for concern given the tide of commercialization, growing number of unstudied high potency products, and the favorable media coverage promoting use.
Supplementary Material
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Footnotes
Funding: This work was supported, in part, by the National Heart, Lung, and Blood Institute (1R01HL130484 [Dr Keyhani]). The funder had no role in the design and conduct of the study; collection, management, analysis, and of the data; preparation, review, or approval of the manuscript; and decision to the manuscript for publication.
Disclosures: The views expressed in this article are those of the authors and do not represent the views of the VA or the US government. The authors report no conflicts of interest.
REFERENCES
- The American Association for Public Opinion Research (US). Standard Definitions: Final Dispositions of Case Codes and outcomes Rates for Surveys. 9th ed. Oakbrook Terrace; IL: 2016. [Google Scholar]
- Abraham A, Zhang AJ, Ahn R, et al. Media content analysis of marijuana's health effects in news coverage. J Gen Intern Med 2018; 33:1438–1440. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Barrus DG, Capogrossi KL, Cates SC, et al. Tasty THC: promises and challenges of cannabis edibles. Methods Report RTI Press 2016; doi: 10.3768/rtipress.2016.op.0035.1611. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Bierut T, Krauss MJ, Sowles SJ, et al. Exploring marijuana advertising on Weedmaps, a popular online directory. Prev Sci 2017; 18:183–192. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Carliner H, Brown QL, Sarvet AL, et al. Cannabis use, attitudes, and legal status in the US: a review. Prev Med 2017; 104:13–23. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Center for Behavioral Health Statistics and Quality (US). 2017 National Survey on Drug Use and Health: Detailed Tables. Rockville (MD); 2018. [Google Scholar]
- Cerdá M, Wall M, Feng T, et al. Association of state recreational marijuana laws with adolescent marijuana use. JAMA Pediatr 2017; 171:142–149. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Charilaou P, Agnihotri K, Garcia P, et al. Trends of cannabis use disorder in the inpatient: 2002 to 2011. Am J Med 2017; 130:678–687. [DOI] [PubMed] [Google Scholar]
- Chu YWL. The effects of medical marijuana laws on illegal marijuana use. J Health Econ 2014; 3:43–61. [DOI] [PubMed] [Google Scholar]
- Compton WM, Han B, Jones CM, et al. Marijuana use and use disorders in adults in the USA, 2002–14: analysis of annual cross-sectional surveys. Lancet Psychiatry 2016; 3:954–964. [DOI] [PubMed] [Google Scholar]
- D’Amico EJ, Miles JN, Tucker JS. Gateway to curiosity: medical marijuana ads and intention and use during middle school. Psychol Addict Behav 2015; 29:613. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Fant RV, Heishman SJ, Bunker EB, et al. Acute and residual effects of marijuana in humans. Pharmacol Biochem Behav 1998; 60 (4):777–784. [DOI] [PubMed] [Google Scholar]
- Fiala SC, Dilley JA, Firth CL, et al. Exposure to marijuana marketing after legalization of retail sales: Oregonians’ experiences, 2015-2016. Am J Public Health 2018; 108:120–127. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Fowler FJ, Jr, Gerstein BS, Barry MJ. How patient centered are medical decisions? Results of a national survey. JAMA Intern Med 2013; 173:1215–1221. [DOI] [PubMed] [Google Scholar]
- Ghasemiesfe M, Ravi D, Vali M, et al. Marijuana use, respiratory symptoms, and pulmonary function: a systematic review and meta-analysis. Ann Intern Med 2018; 169:106–115. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Glantz SA, Halpern-Felsher B, Springer ML. Marijuana, secondhand smoke, and social acceptability. JAMA Intern Med 2018; 178:13–14. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hanauer DA, Zheng K, Singer DC, et al. Public awareness, perception, and use of online physician rating sites. JAMA 2014; 311:734–735. [DOI] [PubMed] [Google Scholar]
- Hasin DS. US epidemiology of cannabis use and associated problems. Neuropsychopharmacology 2018; 43:195. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hasin DS, Sarvet AL, Cerdá M, et al. US Adult illicit cannabis use, cannabis use disorder, and medical marijuana laws: 1991–1992 to 2012–2013. JAMA Psychiatry 2017; 74:579–588. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Heeren T, Edwards EM, Dennis JM, et al. A comparison of results from an alcohol survey of a prerecruited Internet panel and the National Epidemiologic Survey on Alcohol and Related Conditions. Alcohol Clin Exp Res 2008; 32:222–229. [DOI] [PubMed] [Google Scholar]
- Keyhani S, Steigerwald S, Ishida J, et al. Risks and benefits of marijuana use. Ann Intern Med 2018; 169:282–290. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Khatapoush S, Hallfors D. Sending the wrong message”: did medical marijuana legalization in California change attitudes about and use of marijuana? J Drug Issues 2004; 34:751–770. [Google Scholar]
- Kim KH, Kabir E, Kabir S. A review on the human health impact of airborne particulate matter. Environ Int 2015; 74:136–143. [DOI] [PubMed] [Google Scholar]
- Krauss MJ, Sowles SJ, Sehi A, et al. Marijuana advertising exposure among current marijuana users in the US. Drug Alcohol Depend 2017; 174:192–200. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lewis M. Pot sales reach new high of $1. 1 billion in 2016. The Washington Times: KIRO7 2017. [Google Scholar]
- Loria K. 23 Health Benefits of Marijuana [Internet]. Business Insider. Business Insider; 2018. Available at: https://www.businessinsider.com/health-benefits-of-medical-marijuana-2014-4. Accessed March 15, 2019. [Google Scholar]
- Loria K, Welsh J. 21 Health Benefits of Marijuana [Internet]. Business Insider Australia. Business Insider Australia; 2015. Available at: https://www.businessinsider.com.au/facts-on-marijuana-and-health-2015-4. Accessed March 15, 2019. [Google Scholar]
- Martins SS, Mauro CM, Santaella-Tenorio J, et al. State-level medical marijuana laws, marijuana use and perceived availability of marijuana among the general US population. Drug Alcohol Depend 2016; 169:26–32. [DOI] [PMC free article] [PubMed] [Google Scholar]
- McAfee T, Davis KC, Alexander RL, Jr, et al. Effect of the first federally funded US antismoking national media campaign. Lancet 2013; 382:2003–2011. [DOI] [PubMed] [Google Scholar]
- National Academies of Sciences, Engineering, and Medicine. The Health Effects of Cannabis and Cannabinoids: The Current State of Evidence and Recommendations for Research. National Academies Press; 2017. [PubMed] [Google Scholar]
- National Conference of State Legislatures (US). State Medical Marijuana Laws [Internet]. Denver (CO): National Conference of State Legislatures; 2019. Available at: http://www.ncsl.org/research/health/state-medical-marijuana-laws.aspx. Accessed March 15, 2019. [Google Scholar]
- Nugent SM, Morasco BJ, O’Neil ME, et al. The effects of cannabis among adults with chronic pain and an overview of general harms: a systematic review. Ann Intern Med 2017; 167:319–331. [DOI] [PubMed] [Google Scholar]
- Pope CA, Brook RD, Burnett RT, et al. How is cardiovascular disease mortality risk affected by duration and intensity of fine particulate matter exposure? An integration of the epidemiologic evidence. Air Qual Atmosphere Health 2011; 4:5–14. [Google Scholar]
- Richter KP, Levy S. Big marijuana: lessons from big tobacco. N Engl J Med 2014; 371:399–401. [DOI] [PubMed] [Google Scholar]
- Sarvet AL, Wall MM, Keyes KM, et al. Recent rapid decrease in adolescents’ perception that marijuana is harmful, but no concurrent increase in use. Drug Alcohol Depend 2018; 186:68–74. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Steigerwald S, Wong PO, Khorasani A, et al. The form and content of cannabis products in the United States. J Gen Intern Med 2018; 33:1426–1428. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Tomlinson T, De Vries R, Ryan K, et al. Moral concerns and the willingness to donate to a research biobank. JAMA 2015; 313:417–419. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Wang X, Derakhshandeh R, Liu J, et al. One minute of marijuana second-hand smoke exposure substantially impairs vascular endothelial function. J Am Heart Assoc 2016; 5 (8):e003858. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Wen H, Hockenberry JM, Cummings JR. The effect of medical marijuana laws on adolescent and adult use of marijuana, alcohol, and other substances. J Health Econ 2015; 42:64–80. [DOI] [PubMed] [Google Scholar]
- Whiting PF, Wolff RF, Deshpande S, et al. Cannabinoids for medical use: a systematic review and meta-analysis. JAMA 2015; 313 (24):2456–2473. [DOI] [PubMed] [Google Scholar]
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