Table 1:

Baseline characteristics of 1945 women with known baseline menopausal status and cognitive assessments, by baseline menopausal status: Mean (SD) or N (%).

	Menopausal Status at Baseline			p-value*
	Pre- or <5 years Postmenopausal N=594	5–10 years Postmenopausal N=388	>10 years Postmenopausal N=963
Intervention arm				0.2154
DSE	281 (47.3%)	189 (48.7%)	498 (51.7%)
ILI	313 (52.7%)	199 (51.3%)	465 (48.3%)
Baseline Age	52.1 (5.0)	57.6 (4.0)	61.3 (5.6)	<.0001
Age at Cognitive Assessment	64.4 (4.7)	69.6 (3.8)	73.2 (5.6)	<.0001
BMI, kg/m2				<.0001
25–29	74 (12.5%)	47 (12.1%)	173 (18.0%)
30–39	350 (58.9%)	251 (64.7%)	606 (62.9%)
40+	170 (28.6%)	90 (23.2%)	184 (19.1%)
Parity	509 (85.7%)	334 (86.1%)	879 (91.6%)	0.0004
Education				0.0383
<13 years	132 (22.9%)	101 (26.7%)	260 (28.0%)
13–16 years	238 (41.3%)	140 (36.9%)	389 (41.8%)
>16 years	207 (35.9%)	138 (36.4%)	281 (30.2%)
Race/Ethnicity				0.0021
White	298 (50.2%)	210 (54.1%)	504 (52.3%)
Black	110 (18.5%)	68 (17.5%)	205 (21.3%)
Hispanic	93 (15.7%)	75 (19.3%)	165 (17.1%)
Other	93 (15.7%)	35 (9.0%)	89 (9.2%)
Ever used hormone therapy	227 (38.3%)	239 (62.9%)	662 (69.6%)	<.0001
Diabetes duration (years)	5.9 (5.7)	6.2 (6.6)	6.8 (6.6)	0.0096
HbA1c%	7.4 (1.3)	7.2 (1.0)	7.2 (1.1)	0.0002
Hypertension	448 (75.4%)	306 (78.9%)	826 (85.8%)	<.0001
Self-reported cognitive difficulties
Memory	139 (23.5)	105 (27.2)	236 (24.6)	0.41
Problem-solving	79 (13.4)	46 (11.9)	109 (11.3)	0.49
Decision-making	105 (17.7)	67 (17.3)	161 (16.7)	0.89
CVD history	23 (3.9%)	30 (7.7%)	98 (10.2%)	<.0001
APOE4 status				0.4148
Non-carrier	354 (74.8%)	227 (77.0%)	610 (78.0%)
Carrier – one copy	107 (22.6%)	61 (20.7%)	162 (20.7%)
Carrier – two copies	12 (2.5%)	7 (2.4%)	10 (1.3%)

^*p-values are from chi-square tests of association for categorical variables, and one-way ANOVAs for continuous variables.