Table 2:

Adjusted^* mean cognitive assessment scores by intervention assignment, and baseline menopausal status.

	Pre- or <5 years Post-menopausal		5–10 years Post-menopausal		>10 years Post-menopausal		Relative Intervention Effects Mean (SE): ILI Minus DSE			p-values
	DSE	ILI	DSE	ILI	DSE	ILI	Pre- or <5 years Post	5–10 years Post	>10 years Post	Overall Interaction of Intervention by Menopause	Intervention Effect in Pre/<5 yrs. vs >10 yrs.
Average % weight change	2.07 (0.50)	4.52 (0.50)	1.28 (0.57)	4.85 (0.57)	2.10 (0.43)	6.16 (0.43)	2.45 (0.55)	3.57 (0.68)	4.06 (0.43)	0.0675	0.0206
Composite z-score	0.10 (0.05)	0.21 (0.05)	0.001 (0.06)	−0.03 (0.06)	−0.23 (0.04)	−0.29 (0.04)	0.10 (0.05)	−0.03 (0.07)	−0.06 (0.04)	0.0636	0.0216
3MSE	91.0 (0.48)	91.5 (0.47)	90.6 (0.54)	90.1 (0.54)	89.0 (0.41)	89.1 (0.41)	0.57 (0.52)	−0.47 (0.64)	0.11 (0.41)	0.4510	0.4864
Stroop**	31.3 (1.31)	30.1 (1.30)	33.1 (1.48)	35.7 (1.48)	37.5 (1.13)	40.0 (1.12)	−1.19 (1.43)	2.65 (1.76)	2.46 (1.13)	0.0956	0.0446
DSST	39.8 (0.77)	41.7 (0.76)	38.7 (0.86)	38.3 (0.86)	35.6 (0.66)	34.6 (0.65)	1.91 (0.83)	−0.35 (1.02)	−0.99 (0.65)	0.0213	0.0061
Trails (Part B)**	118.6 (5.0)	114.6 (4.9)	121.4 (5.6)	120.7 (5.6)	138.0 (4.3)	144.8 (4.2)	−0.96 (5.35)	−0.75 (6.60)	6.76 (4.24)	0.2631	0.1166
AVLT Delayed	8.72 (0.25)	9.13 (0.24)	8.00 (0.28)	8.22 (0.28)	7.66 (0.21)	7.59 (0.21)	0.41 (0.27)	0.22 (0.33)	−0.06 (0.21)	0.3700	0.1665

^*In addition to intervention and baseline menopausal status, models are adjusted for whether or not cognitive function had been assessed previously and the following baseline factors: education, race/ethnicity, CVD history, hypertension status, and HbA1c%. Adjustment for the average percent weight change across all follow-up visits did not affect the results (data not shown).

^**Higher scores reflect poorer performance

Bold p<0.05

3MSE: Modified Mini Mental State Examination

DSST: Digital Symbol Substitution Test

AVLT: Auditory-Verbal Learning Test