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. 2020 May 5;39(23):4538–4550. doi: 10.1038/s41388-020-1307-3

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a The expression of LINC01278 in paired HCC tissues and adjacent normal tissues in TCGA datasets (n = 49) and SYSUCC dataset (n = 20). b Correlation of recurrence-free survival (RFS) and overall survival (OS) and LINC01278 expression by Kaplan–Meier analysis in SYSUCC dataset. c The wound-healing assay in HCC cells. d The invasion assay in HCC cells. e The Smad2/3 mRNA expression of HCC cells transfected by LINC01278, shLINC01278, LINC01278+miR-1258, and shLINC01278+anti-miRNA-1258. f The protein expression of Smad2 and Smad3 in HCC cells transfected by LINC01278, shLINC01278, LINC01278+miR-1258, and shLINC01278+anti-miRNA-1258. g The protein levels of P-Smad2, Smad2, P-Smad3, Smad3, PAI-1, E-cadherin, and vimentin in metastasis tumor tissues. LINC01278, ectopic LINC01278 expression in HCC cells. h The lung metastasis of HCC cells transfected by LINC01278 and shLINC01278. shLINC01278, HCC cells were transfected by shRNA target LINC01278. miR-1258, HCC cells were transfected by miR-1258 expression vector. Anti-miR-1258, HCC cells were transfected by miR-1258 antisense plasmid. *P < 0.05.