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. 2020 Jun 4;129:110337. doi: 10.1016/j.biopha.2020.110337

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© 2020 The Authors

Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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Fig. 1 — (A) The novel coronavirus structure. (B) Spike protein consists of two subunits S1 and S2. Studies have shown that COVID-19 through ACE2 receptor binds to human epithelial cells. ACE2 is used as its receiver to the host. The connection between the amplitude of the receptor binding in the spike protein and the cell receptor mediated by membrane fusion and the onset of the virus life cycle.