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. 2020 May 15;12(5):1714–1727.

Figure 6.

Figure 6

The systemic PBN reduced the phosphorylation of NR2B induced by type-2 diabetic neuropathic pain. (A, B) The treatment with PBN at 14 days after STZ injection significantly reversed the type-2 diabetes-induced thermal hyperalgesia (A) and mechanical allodynia (B) (n=4). *P<0.05, compared with the DNP group. (C) The western blot assay revealed that p-NR2B and total NR2B expression changed in each group at 17, 21 and 28 days after STZ injection. (D) Quantification of the western blot data obtained from [C]. All data were presented as mean ± standard error of the mean (SEM), n=4. *P<0.05, **P<0.01, ***P<0.001.