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. 2020 May 15;12(5):2257–2266.

Figure 4.

Figure 4

NORAD and SEPT2 shared binding site in miR-144-3p. A. Binding region between NORAD and miR-144-3p. B. Luciferase activity in HCC cells harboring wt/mt-NORAD and miR-144-3p mimic or miR-NC showed luciferase activity can be decreased by miR-144-30 mimic in cells with wt-NORAD. C. miR-144-3p expression was decreased in HCC tissues compared with normal tissues. D. Negatively correction of NORAD and miR-144-3p in HCC tissues. E. Binding region between SEPT2 and miR-144-3p. F. Luciferase activity in HCC cells harboring wt/mt-SEPT2 and miR-144-3p mimic or miR-NC showed luciferase activity can be decreased by miR-144-30 mimic in cells with wt-SEPT2. G. SEPT2 expression was increased in HCC tissues compared with normal tissues. H. RIP assay indicated that NORAD, miR-144-3p, and SEPT2 were co-enriched in anti-Ago2 group compared with anti-IgG group. I. Negatively correction of SEPT2 and miR-144-3p in HCC tissues. J. Positively correction of SEPT2 and NORAD in HCC tissues. NORAD: non-coding RNA activated by DNA damage; HCC: hepatocellular carcinoma; miR-144-3p: microRNA-144-3p; SEPT2: septin 2; wt: wild-type; mt: mutant; miR-NC: negative control microRNA.