Table 3.
Correlation of SOCS family members with TP53 status in OC patients
| Gene | TP53 status | Case-low1 | Case-high2 | HR (95% CI) | p-value |
|---|---|---|---|---|---|
| SOCS1 | wide type | 29 | 65 | 1.63 (0.9-2.94) | 0.1 |
| mutated | 377 | 129 | 1.29 (1-1.66) | 0.049* | |
| SOCS2 | wide type | 8 | 11 | 2.87 (0.9-9.12) | 0.063 |
| mutated | 71 | 53 | 1.48 (1.01-2.17) | 0.043* | |
| SOCS3 | wide type | 9 | 10 | 0.69 (0.25-1.92) | 0.48 |
| mutated | 42 | 82 | 0.66 (0.45-0.98) | 0.039* | |
| SOCS4 | wide type | 7 | 12 | 2.28 (0.76-6.82) | 0.13 |
| mutated | 36 | 88 | 0.68 (0.45-1.02) | 0.058 | |
| SOCS5 | wide type | 23 | 71 | 2.58 (1.2-5.53) | 0.012* |
| mutated | 126 | 380 | 1.23 (0.94-1.62) | 0.12 | |
| SOCS6 | wide type | 8 | 11 | 3.15 (1.05-9.46) | 0.032* |
| mutated | 90 | 34 | 1.34 (0.88-2.04) | 0.18 | |
| SOCS7 | wide type | 5 | 14 | 1.57 (0.49-4.96) | 0.44 |
| mutated | 49 | 75 | 0.68 (0.46-0.99) | 0.045* | |
| CIS | wide type | 7 | 12 | 0.26 (0.08-0.82) | 0.014* |
| mutated | 34 | 90 | 1.47 (0.95-2.28) | 0.082 |
Cases-low: patient number-low expression of the corresponding gene.
Cases-high: patient number-high expression of the corresponding gene.
P < 0.05.