Table 2.
The prognostic factors for total liposarcoma patients with distant metastasis diagnosed between 2010 and 2016 by Cox regression
| Subject characteristics | Univariate | Multivariate | ||
|---|---|---|---|---|
|
|
|
|||
| HR (95% CI) | P-value | HR (95% CI) | P-value | |
| Sex | ||||
| Male | 1.00 (Reference) | 1.00 (Reference) | ||
| Female | 0.91 (0.66-1.27) | 0.592 | 0.74 (0.49-1.12) | 0.159 |
| Age (year) | ||||
| <60 | 1.00 (Reference) | 1.00 (Reference) | ||
| ≥60 | 1.33 (0.96-1.84) | 0.082 | 1.73 (1.11-2.69) | 0.015 |
| Race | ||||
| White | 1.00 (Reference) | |||
| Black | 1.26 (0.75-2.13) | 0.385 | NA | NA |
| AI | 4.66 (0.64-33.87) | 0.128 | NA | NA |
| API | 0.96 (0.54-1.70) | 0.878 | NA | NA |
| Insurance recode | ||||
| Insured | 1.00 (Reference) | |||
| Uninsured | 1.30 (0.75-2.26) | 0.344 | NA | NA |
| Marital status | ||||
| Married | 1.00 (Reference) | |||
| Unmarried | 1.24 (0.90-1.72) | 0.195 | NA | NA |
| Primary site | ||||
| Extremities | 1.00 (Reference) | 1.00 (Reference) | ||
| Trunk | 1.49 (0.98-2.26) | 0.062 | 1.10 (0.66-1.86) | 0.708 |
| RIA | 1.93 (1.23-3.04) | 0.005 | 1.31 (0.77-2.22) | 0.319 |
| Thorax | 2.02 (0.62-6.61) | 0.243 | 0.76 (0.17-3.49) | 0.728 |
| Others | 2.16 (1.09-4.28) | 0.027 | 4.96 (1.03-23.88) | 0.046 |
| Histology | ||||
| Well-Differentiated | 1.00 (Reference) | |||
| Dedifferentiated | 1.16 (0.65-2.07) | 0.618 | NA | NA |
| Myxoid | 0.68 (0.36-1.28) | 0.233 | NA | NA |
| Pleomorphic | 1.37 (0.67-2.79) | 0.389 | NA | NA |
| Others | 0.36 (0.10-1.26) | 0.111 | NA | NA |
| Grade | ||||
| Grade I | 1.00 (Reference) | |||
| Grade II | 0.91 (0.45-1.84) | 0.799 | NA | NA |
| Grade III | 1.17 (0.65-2.09) | 0.603 | NA | NA |
| Grade IV | 1.50 (0.87-2.58) | 0.149 | NA | NA |
| T stage | ||||
| T1 | 1.00 (Reference) | 1.00 (Reference) | ||
| T2 | 1.06 (0.49-2.28) | 0.880 | 1.16 (0.48-2.76) | 0.744 |
| N stage | ||||
| N0 | 1.00 (Reference) | 1.00 (Reference) | ||
| N1 | 1.51 (0.90-2.51) | 0.117 | 0.98 (0.50-1.92) | 0.963 |
| Number of Met | ||||
| ≤1 | 1.00 (Reference) | 1.00 (Reference) | ||
| >1 | 2.10 (1.43-3.09) | <0.001 | 1.46 (0.79-2.71) | 0.225 |
| Surg (prim) | ||||
| None | 1.00 (Reference) | 1.00 (Reference) | ||
| Yes | 0.35 (0.25-0.48) | <0.001 | 0.26 (0.17-0.41) | <0.001 |
Abbreviations: SEER: Surveillance, Epidemiology, and End Result; Met = Metastases. RIA: Retroperitoneal/intra-abdominal; IA: Indian/Alaska Native; API: Asian or Pacific Islander; Surg (prim): Surgery for primary site.