Table 3.
The risk factors for survival in liposarcoma patients with distant metastasis diagnosed between 2010 and 2016 by logistic regression analysis
| Subject characteristics | Total Met (Univariate) | Total Met (Multivariate) | Lung Met (Multivariate) | Liver Met (Multivariate) | Bone Met (Multivariate) | |||||
|---|---|---|---|---|---|---|---|---|---|---|
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|
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|
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| OR (95% CI) | P-value | OR (95% CI) | P-value | OR (95% CI) | P-value | OR (95% CI) | P-value | OR (95% CI) | P-value | |
| Sex | ||||||||||
| Male | 1.00 (Reference) | 1.00 (Reference) | 1.00 (Reference) | 1.00 (Reference) | 1.00 (Reference) | |||||
| Female | 0.84 (0.64-1.11) | 0.225 | 0.87 (0.58-1.29) | 0.487 | 0.71 (0.36-1.40) | 0.327 | 1.37 (0.56-3.34) | 0.488 | 0.80 (0.33-1.93) | 0.623 |
| Age (year) | ||||||||||
| <60 | 1.00 (Reference) | 1.00 (Reference) | 1.00 (Reference) | 1.00 (Reference) | 1.00 (Reference) | |||||
| ≥60 | 1.34 (1.02-1.75) | 0.035 | 1.37 (0.92-2.06) | 0.123 | 1.12 (0.58-2.13) | 0.739 | 2.71 (0.99-7.43) | 0.053 | 1.16 (0.47-2.83) | 0.750 |
| Race | ||||||||||
| White | 1.00 (Reference) | 1.00 (Reference) | ||||||||
| Black | 1.00 (0.63-1.59) | 1.000 | NA | NA | NA | NA | 0.59 (0.07-4.81) | 0.626 | NA | NA |
| AI | 0.49 (0.07-3.59) | 0.483 | NA | NA | NA | NA | NA | NA | NA | NA |
| API | 1.03 (0.66-1.63) | 0.888 | NA | NA | NA | NA | 2.16 (0.69-6.72) | 0.184 | NA | NA |
| Insurance recode | ||||||||||
| Insured | 1.00 (Reference) | 1.00 (Reference) | 1.00 (Reference) | 1.00 (Reference) | ||||||
| Uninsured | 2.07 (1.17-3.66) | 0.013 | 2.06 (0.83-5.10) | 0.120 | NA | NA | 10.36 (2.27-47.30) | 0.003 | 4.28 (1.05-17.48) | 0.043 |
| Marital status | ||||||||||
| Married | 1.00 (Reference) | 1.00 (Reference) | ||||||||
| Unmarried | 1.26 (0.95-1.66) | 0.107 | NA | NA | NA | NA | 1.18 (0.48-2.93) | 0.719 | NA | NA |
| Primary site | ||||||||||
| Extremities | 1.00 (Reference) | 1.00 (Reference) | 1.00 (Reference) | 1.00 (Reference) | 1.00 (Reference) | |||||
| Trunk | 2.22 (1.59-3.10) | <0.001 | 1.69 (1.02-2.79) | 0.040 | 1.56 (0.70-3.48) | 0.281 | 1.85 (0.46-7.42) | 0.385 | 1.03 (0.38-2.78) | 0.950 |
| RIA | 2.19 (1.52-3.14) | <0.001 | 1.53 (0.86-2.73) | 0.150 | 0.80 (0.30-2.14) | 0.657 | 6.16 (1.59-23.81) | 0.008 | 0.17 (0.02-1.47) | 0.107 |
| Thorax | 3.44 (1.01-11.66) | 0.048 | 2.65 (0.54-13.09) | 0.232 | 2.64 (0.31-22.84) | 0.377 | NA | NA | 7.24 (1.23-42.68) | 0.029 |
| Others | 6.06 (3.10-11.84) | <0.001 | 1.09 (0.20-5.84) | 0.917 | 1.47 (0.15-14.07) | 0.736 | 1.96 (0.07-58.35) | 0.697 | 1.28 (0.09-18.29) | 0.856 |
| Histology | ||||||||||
| Well-Differentiated | 1.00 (Reference) | 1.00 (Reference) | 1.00 (Reference) | 1.00 (Reference) | 1.00 (Reference) | |||||
| Dedifferentiated | 7.92 (4.89-12.83) | <0.001 | 1.97 (0.82-4.71) | 0.127 | 5.62 (1.41-22.37) | 0.014 | 2.66 (0.44-16.01) | 0.285 | 1.24 (0.16-9.69) | 0.836 |
| Myxoid | 4.26 (2.55-7.13) | <0.001 | 2.65 (1.16-6.05) | 0.020 | 1.54 (0.35-6.85) | 0.567 | 7.60 (1.51-38.20) | 0.014 | 2.25 (0.35-14.33) | 0.392 |
| Pleomorphic | 5.92 (3.21-10.93) | <0.001 | 1.95 (0.70-5.43) | 0.204 | 5.93 (1.26-27.91) | 0.024 | 3.35 (0.24-46.59) | 0.367 | 2.95 (0.35-24.84) | 0.321 |
| Others | 4.90 (2.12-11.31) | <0.001 | 2.13 (0.65-7.04) | 0.214 | 8.03 (1.56-41.43) | 0.013 | 6.39 (0.53-77.04) | 0.144 | 2.81 (0.28-28.22) | 0.381 |
| Grade | ||||||||||
| Grade I | 1.00 (Reference) | 1.00 (Reference) | 1.00 (Reference) | 1.00 (Reference) | 1.00 (Reference) | |||||
| Grade II | 3.40 (1.97-5.84) | <0.001 | 1.74 (0.79-3.84) | 0.170 | 0.11 (0.01-1.02) | 0.052 | 0.88 (0.19-4.07) | 0.869 | 2.41 (0.44-13.08) | 0.309 |
| Grade III | 5.35 (3.30-8.68) | <0.001 | 2.62 (1.17-5.88) | 0.019 | 0.56 (0.16-2.01) | 0.377 | 2.35 (0.53-10.36) | 0.258 | 3.93 (0.66-23.42) | 0.133 |
| Grade IV | 9.14 (5.81-14.36) | <0.001 | 4.07 (1.84-9.00) | 0.001 | 1.46 (0.45-4.73) | 0.529 | 0.87 (0.16-4.81) | 0.873 | 3.09 (0.50-19.26) | 0.227 |
| T stage | ||||||||||
| T1 | 1.00 (Reference) | 1.00 (Reference) | 1.00 (Reference) | 1.00 (Reference) | 1.00 (Reference) | |||||
| T2 | 2.06 (1.11-3.82) | 0.022 | 2.71 (1.15-6.40) | 0.023 | 6.34 (0.85-47.49) | 0.072 | 1.17 (0.24-5.74) | 0.842 | 4.35 (0.57-33.47) | 0.158 |
| N stage | ||||||||||
| N0 | 1.00 (Reference) | 1.00 (Reference) | 1.00 (Reference) | 1.00 (Reference) | 1.00 (Reference) | |||||
| N1 | 13.45 (7.99-22.63) | <0.001 | 9.44 (4.63-19.26) | <0.001 | 7.55 (2.72-20.95) | <0.001 | 24.17 (7.86-74.30) | <0.001 | 13.67 (3.72-50.29) | <0.001 |
Abbreviations: SEER: Surveillance, Epidemiology, and End Result; Met = Metastases. RIA: Retroperitoneal/intra-abdominal; IA: Indian/Alaska Native; API: Asian or Pacific Islander; Surg (prim): Surgery for primary site.