Table 9.
Esophageal cancer and its associated circRNAs
| CircRNA | Sample | Expression | Mechanism | Function | Reference |
|---|---|---|---|---|---|
| cir-ITCH | Tissue | Down | Sponges miRNA-7, miRNA-17, miRNA-214, targets Wnt/β-catenin pathway | Inhibits tumor progression | [99] |
| has_circ_0067934 | Tissue | Up | - | Poor differentiation and lower TNM stage, promotes proliferation and migration | [100] |
| circRNA_100876 | Tissue and cell | Up | - | Poor prognosis, promotes cell proliferation and metastasis | [101] |
| ciRS-7 | Tissue and cell | Up | Sponges miRNA-7, miRNA-876-5p, targets KLF4, HOXB13, MAGE-A, and NF-κB pathways | Promotes cell growth, migration, invasion, and metastasis | [102-104] |
| hsa_circ_0000337 | Tissue and cell | Up | Sponges miRNA-670-5p | Promotes cell proliferation, migration and invasion | [105] |
| hsa_circ_0006168 | Tissue and cell | Up | Sponges miRNA-100, targets rapamycin (mTOR) | Promotes cell proliferation, migration and invasion | [106] |
| circ0043898 | Tissue | Down | Targets histone H3 and BMI1 | Inhibits cell proliferation, migration and invasion and induces cell apoptosis and death | [107] |
| circVRK1 | Tissue and cell | Down | Sponges miRNA-624-3p, targets PTEN/PI3K/AKT pathway | Tumor suppression, radioresistance | [110] |
| circ-TTC17 | Tissue, cell and plasma | Up | Sponges miRNAs | Promotes cell proliferation and migration | [108] |
| circ-SMAD7 | Plasma and tissue | Down | - | Promotes cell proliferation and migration | [109] |