Table 4.

Univariate and multivariate Cox regression analyses of survival according to the eight-KIF signature in the training set and the validation set of HCC patients

Training set (TCGA-LIHC)
Variable	Univariate analysis			Multivariate analysis
	HR	95% CI	p-Value	HR	95% CI	p-Value
Gender	1.3117	0.901-1.910	0.1567	1.1561	0.781-1.711	0.4685
Age	1.0129	0.998-1.028	0.0872	1.0126	0.997-1.028	0.1033
Stage	1.6557	1.354-2.024	0.0000	1.5891	1.288-1.960	0.0000
Grade	1.1398	0.888-1.464	0.3051	1.1567	0.884-1.514	0.2890
Risk score	1.2368	1.146-1.335	0.0000	1.1805	1.086-1.283	0.0001
Validation set (ICGA-LIRI-JP)
Variable	Univariate analysis			Multivariate analysis
	HR	95% CI	p-Value	HR	95% CI	p-Value
Gender	1.9286	1.037-3.594	0.0387	2.7536	1.450-5.228	0.002
Age	1.0020	0.972-1.033	0.8985	0.9937	0.961-1.028	0.7126
Stage	2.1546	1.493-3.110	0.0000	2.3469	1.626-3.387	0.0000
Grade	1.7510	0.773-3.965	0.1791	1.9613	0.802-4.798	0.1400
Risk score	2.58E+52	1.2E+35-5.2E+69	0.0000	7.37E+52	2.9E+34-1.9E+71	0.0000

HR: hazard ratio; CI: confidence interval.