Figure 6.

Results of bioinformatic analysis for predicting transcriptional regulation of RNASE2A. A. Identification of transcription factors that may regulate RNASEH2A was based on a prediction by the UCSC Genome Browser and co-expression analyses. B. Schematic representation of the transcription factors on the RNASEH2A promoter relative to the transcription start site (TSS). C. Gene-set enrichment analyses and prognosis of ER-positive breast cancer patients. D. Linear regression analysis between RNASEH2A and ESR1 expression in TCGA dataset-2. E. ESR1 mRNA expression in the ER-positive and ER-negative groups. TF, transcription factor; IHC, immunohistochemical stain; ESR1, estrogen receptor 1; ER, estrogen receptor.