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Schematic representation of ACPP-Cy5 nanosystem for targeting and imaging colorectal cancer. Cellular uptake caused by the polycation peptide is prevented by the polyanion peptide connected by a cleavable domain. Once the connecting domain is cleaved by MMP-2/9, the polyanion inhibitory domain will detach, and the polycation domain along with the Cy5 label can freely penetrate into cells.
