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. 2020 Jun 3;10:9058. doi: 10.1038/s41598-020-65825-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Linear correlations between PLA2R1 promoter methylation and blast cell occurrence measured at the time of diagnosis and during childhood ALL treatment protocol. The scatter blots show the relative blast cell numbers plotted against the PLA2R1 methylation percentages determined in BM aspirates (A) and PB samples (B) at the time of diagnosis (white dots) and following ALL treatment protocol (black dots). The percentage of PLA2R1 promoter methylation was defined using ddPCR. The relative blast cell number (number of blast cells in relation to the number of total leukocytes in %) was determined using light microscopic and flow cytometric analyses. Significant positive correlations between the relative blast cell number and the PLA2R1 methylation percentage were detected for BM aspirates (r = 0.92, p < 0.001, n = 98) and PB samples (r = 0.91, p < 0.001, n = 98). The patient with high relative blast cell numbers and low PLA2R1 promoter methylation at diagnosis is indicated by bold circles for BM and PB samples. Dashed lines indicate the 97.5^th percentile of the PLA2R1 promoter methylation in the healthy control group.