Fig. 4. Effect of inactivating OFC top-down projection on V1 responses.
a Schematic of laser stimulation. b Normalized responses to Go stimulus with and without inactivating OFC axons. c Distribution of rate change induced by inactivating OFC axons during Go trials. P = 0.87, n = 116 neurons. d Inactivating OFC axons during Go trials did not affect hit rate (P = 0.26) or CR rate (P = 0.11, n = 15 sessions from seven mice). e Schematic of laser stimulation. f Inactivating OFC axons during No–Go trials significantly reduced the SI of V1 neurons (**P = 0.007, n = 169). g Normalized responses to No–Go stimulus in FA and CR trials, respectively, with and without laser stimulation. h Inactivating OFC axons during No–Go trials increased the responses of V1 neurons in CR (***P = 1.02 × 10−6) but not in FA trials (P = 0.66). n = 169 neurons. i Inactivating OFC axons during No–Go trials significantly reduced MI amplitude (***P = 6.4 × 10−4, n = 169 neurons). j Rate change for early response component (CR, P = 0.18; FA, P = 0.77). k Rate change for late response component (CR, ***P = 2.4 × 10−5; FA: P = 0.75). l Laser-off vs laser-on MI for early component (P = 0.78). m Laser-off vs laser-on MI for late component (***P = 6.4 × 10−5). n Effect of laser stimulation during No–Go trials on the percentage of trials with licks in the waiting period. CR, P = 0.14; FA, *P = 0.02. o Effect of laser stimulation on lick rate during waiting period. FA, F(1,17) = 7.78, *P = 0.01; CR, F(1,17) = 1.6, P = 0.22, two-way repeated measures ANOVA. p Inactivating OFC axons during No–Go trials did not affect hit rate (P = 0.56) or CR rate (P = 0.95). For n–p, n = 18 sessions from 14 mice. Wilcoxon two-sided signed rank test was used for c, d, f, h–n, and p. For b–d and f–p, source data are provided as a Source Data file. Shadings and error bars, mean ± s.e.m.