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. 2020 Jun 3;10:9050. doi: 10.1038/s41598-020-65666-x

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(A) Percentages of NK cells and Lox-1⁺ PMN-MDSCs among CD45⁺ T cells in non-responders and responders at 2 weeks after the first round of nivolumab. Dot plots represent frequencies of immune cells, and small horizontal lines indicate means (±SD). (B) Changes in NK frequencies between baseline and after the first nivolumab treatment in non-responders and responders. Each dot indicates a single patient. *P < 0.05, **P < 0.01 (two-tailed Student’s t-test).