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. 2020 Jun 3;10:9024. doi: 10.1038/s41598-020-65920-2

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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hsa_circ_101237 expression in NSCLC tissues and cell lines, and its clinical significance. (A) Determination of hsa_circ_101237 expression in 303 paired samples of the NSCLC tissues. (B) Proportion pie chart and histogram of NSCLC sample that saw the up-regulation of hsa_circ_101237 expression (242/303, 79.87%, red), down-regulation (33/303, 10.89%, blue), or no change (28/303, 9.24%, brown). Expression value of Log2 (T/N) > 1 and < −1 were regarded as as higher and lower expression, respectively, and that in the range of −1–1 was regarded as no obvious change. (C) Based on the qRT-PCR analysis on hsa_circ_101237 expression, hsa_circ_101237 presented up-regulation in NSCLC cells. (D) qRT-PCR helped to determine hsa_circ_101237 expression after RNase R treatment in A549 cell line. (E,F) The prognosis presented by NSCLC patients whose hsa_circ_101237 levels were different was assessed via Kaplan–Meier survival analysis. The cutoff value referred to median hsa_circ_101237 expression level in those NSCLC tissues. *P < 0.05; **P < 0.01; ***P < 0.001.