Table 1.
Concentrations of administered deuterated oxytocin (d5OT) in the brain of monkeys.
| Dose–Route d5OT |
80 IU IN | 40 IU IN | 80 IU IV | |||
|---|---|---|---|---|---|---|
| Monkey ID# (sex) |
ID #2 (M) |
ID #4 (M) |
ID #1 (F) |
ID #5 (F) |
ID #3 (F) |
ID #6 (F) |
| Brain region | BRAIN d5OT concentration pg/mg (nM) | |||||
| Cerebellum | ND | + | ND | ND | ND | ND |
| Brainstem | 0.14 (<1) | 0.24 (1) | + | ND | ND | + |
| Striatum | ND | ND | 2.41 (13) | + | ND | ND |
| Amygdala | ND | ND | NM | + | ND | ND |
| Thalamus | ND | ND | 0.23 (1) | ND | ND | ND |
| Visual cortex | ND | ND | ND | ND | ND | ND |
| Insular cortex | ND | ND | NM | ND | ND | ND |
| dPFC | ND | + | ND | + | ND | + |
| mPFC | ND | ND | ND | ND | ND | + |
| OFC | 2.04 (11) | ND | ND | ND | ND | ND |
| Hypothalamus | ND | ND | ND | |||
| Hippocampus | ND | ND | ND | |||
ND not detected, NM not measured, + detected but not quantifiable, OT oxytocin, dPFC dorsal prefrontal cortex, mPFC medial prefrontal cortex, OFC orbital frontal cortex, CSF cerebrospinal fluid, F female, M male, IN intranasal, IV intravenous.