FIGURE 4.

Plasmid barcodes of bla_NDM–1-carrying plasmids in eight Klebsiella pneumoniae strains. Since the plasmids are linearized by Cas9-targeting bla_NDM–1, all barcode ends are where we locate the bla_NDM–1 gene. For the samples containing two bla_NDM–1 plasmids, sizes are written in brackets to differentiate the plasmids. (A) Identical plasmids with the same sizes (∼125 kb) and the same location of bla_NDM–1. (B) Plasmids encoding bla_NDM–1 that do not match among each other. LO-271 (107.4) and LO-64 were plotted here for reference.