Table 1.
Studies comparing NCPAP and intubation with IMV.
| References | Intervention (n) | GA, weeks | BPD (%) | Death (%) | Combined BPD and death (%) | Intubation rates in NCPAP group (%) |
|---|---|---|---|---|---|---|
| Morley et al. (39) | NCPAP (307) vs. IMV (303) | 25–28 | 29 vs. 35 | 6.5 vs. 5.9 | 34 vs. 39 | 59 |
| SUPPORT et al. (40) | NCPAP (663) vs. IMV (653) | 24–28 | 40 vs. 44 | 14 vs. 17 | 49 vs. 54 | 83 |
| Dunn et al. (41) | NCPAP (223) vs. INSURE (216) vs. IMV (209) | 26–29 | n/a | 4 vs. 7 vs 7 | 30 vs. 28 vs. 36 | 52 |
| Rojas et al. (42) | NCPAP (137) vs. INSURE (141) | 27–30 | 59 vs. 49 | 9 vs. 9 | 62 vs. 54 | 53 |
| Sandri et al. (43) | NCPAP (105) vs. INSURE (103) | 25–29 | n/a | n/a | 21 vs. 22 | 31 |
| Göpel et al. (44) | NCPAP ± LISA (108) vs. nCPAP ± INSURE (112) | 26–28 | 8 vs. 13 | n/a | 14 vs. 15 | 46 |
| Kanmaz et al. (45) | NCPAP + LISA (100) vs. nCPAP INSURE (100) | <30 | 10 vs. 20* | 16 vs. 13 | 34 vs. 45 | 40 |
| Tapia et al. (46) | NCPAP + INSURE (131) vs. MV (125) | 800–1,500 g | 7 vs. 10 | 8 vs. 9 | 14 vs. 19 | 30 |
NCPAP, Nasal continuous positive pressure ventilation; IMV, Invasive mechanical ventilation; INSURE, INtubation, SURfactant and Extubation; LISA, Less invasive surfactant administration; GA, Gestational age (weeks) *P < 0.05.