Fig. 1.

The interconnection network between diseases and microbiota modulating interventions that are considered in clinical trials modulated microbiota in different disorders. In the first step, we picked out all original articles from 260 medical sciences-related documents, which constitute 121original articles, and categorized them into the following four groups: the human studies (69 articles; 57.02%), the in-vitro studies (36 articles; 29.75%), the animal studies (13 articles; 10.74%), and others (3 articles; 2.47%). In the next step, we distinguished the study design of all human studies and included all clinical trials dealing with microbiota modulating interventions in different disorders that finally, 33 clinical trials were carefully reviewed for data extraction